Morpholine → N-[7-(4-Fluoro-phenyl)-4-methoxy-benzooxazol-2-yl]-2-morpholin-4-yl-isonicotinamide

HRID 1611958Notes

Reaction equation

HRID 1611958 reaction equation
Br[C:2]1[CH:3]=[C:4]([CH:26]=[CH:27][N:28]=1)[C:5]([NH:7][C:8]1[O:9][C:10]2[C:16]([C:17]3[CH:22]=[CH:21][C:20]([F:23])=[CH:19][CH:18]=3)=[CH:15][CH:14]=[C:13]([O:24][CH3:25])[C:11]=2[N:12]=1)=[O:6].C(=O)([O-])[O-].[Cs+].[Cs+].[NH:35]1[CH2:40][CH2:39][O:38][CH2:37][CH2:36]1>CN1C(=O)CCC1>[F:23][C:20]1[CH:21]=[CH:22][C:17]([C:16]2[C:10]3[O:9][C:8]([NH:7][C:5](=[O:6])[C:4]4[CH:26]=[CH:27][N:28]=[C:2]([N:35]5[CH2:40][CH2:39][O:38][CH2:37][CH2:36]5)[CH:3]=4)=[N:12][C:11]=3[C:13]([O:24][CH3:25])=[CH:14][CH:15]=2)=[CH:18][CH:19]=1

Participants

5

Reactant 3

HCID 8083MorpholineHCID 10796Cesium carbonateHCID 222522612-bromo-N-[7-(4-fluoro-phenyl)-4-methoxy-benzooxazol-2-yl]-isonicotinamide

Product 1

HCID 10366390N-[7-(4-Fluoro-phenyl)-4-methoxy-benzooxazol-2-yl]-2-morpholin-4-yl-isonicotinamide

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

From 2-bromo-N-[7-(4-fluoro-phenyl)-4-methoxy-benzooxazol-2-yl]-isonicotinamide with cesium carbonate and morpholine in NMP. ES-MS m/e (%): 449 (M+H+, 100).

Sources & evidence

ORD record
ord-35c045dfad37433187005af0d4560c75
Source dataset
uspto-grants-2006_01
Patent number
US06992083B2

Reaction notes

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