HuagongsheHuagongshe Chemistry Print Report · For research reference only
Morpholine → N-(4-Methoxy-7-morpholin-4-yl-benzooxazol-2-yl)-2-morpholin-4-yl-isonicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Cesium carbonate | HCID 10796 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 22252247 | HCID 22252247 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | N-(4-Methoxy-7-morpholin-4-yl-benzooxazol-2-yl)-2-morpholin-4-yl-isonicotinamide | HCID 22252246 | — |
Reaction Steps
From 2-bromo-isonicotinic, HATU and N-diethylisopropylamine in THF, followed by treatment with 4-methoxy-7-morpholin-4-yl-benzooxazol-2-yl-amine in dioxane. Then treatment with cesium carbonate and morpholine in NMP. ES-MS m/e (%): 440 (M+H+, 100).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06992083B2 |
| Source dataset | uspto-grants-2006_01 |
| ORD ID | ord-6151ed3a28594eecbff16c761207b585 |
| Source note | uspto-grants-2006_01 |