HRID1611967

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID8083

Morpholine

C4H9NO

HCID10796

Cesium carbonate

CCs2O3

结构：CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F

HCID9886157

Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)

C10H15F6N6OP

HCID22252247

未命名化合物

PRODUCTS

生成物

结构：COc1ccc(N2CCOCC2)c2oc(NC(=O)c3ccnc(N4CCOCC4)c3)nc12

HCID22252246

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID8028

Tetrahydrofuran

C4H8O

溶剂HCID13387

N-Methyl-2-pyrrolidone

C5H9NO

溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

From 2-bromo-isonicotinic, HATU and N-diethylisopropylamine in THF, followed by treatment with 4-methoxy-7-morpholin-4-yl-benzooxazol-2-yl-amine in dioxane. Then treatment with cesium carbonate and morpholine in NMP. ES-MS m/e (%): 440 (M+H+, 100).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6151ed3a28594eecbff16c761207b585
来源数据集: uspto-grants-2006_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06992083B2
来源说明: uspto-grants-2006_01

反应 SMILES

CN(C(O[N:9]1N=N[C:11]2[CH:12]=[CH:13][CH:14]=[N:15][C:10]1=2)=[N+](C)C)C.F[P-](F)(F)(F)(F)F.[CH3:25][O:26][C:27]1[C:32]2[N:33]=[C:34]([NH2:36])[O:35][C:31]=2[C:30]([N:37]2[CH2:42][CH2:41][O:40][CH2:39][CH2:38]2)=[CH:29][CH:28]=1.[C:43](=[O:46])([O-])[O-].[Cs+].[Cs+].N1[CH2:54][CH2:53][O:52][CH2:51][CH2:50]1>C1COCC1.O1CCOCC1.CN1C(=O)CCC1>[CH3:25][O:26][C:27]1[C:32]2[N:33]=[C:34]([NH:36][C:43](=[O:46])[C:12]3[CH:13]=[CH:14][N:15]=[C:10]([N:9]4[CH2:54][CH2:53][O:52][CH2:51][CH2:50]4)[CH:11]=3)[O:35][C:31]=2[C:30]([N:37]2[CH2:42][CH2:41][O:40][CH2:39][CH2:38]2)=[CH:29][CH:28]=1