2-chloro-6H-thieno[2,3-b]pyrrole-5-carbonyl chloride → 2-{6-[(2-Chloro-6H-thieno[2,3-b]pyrrole-5-carbonyl)-amino]-5-ethoxy-pyridin-3-yl}-2-hydroxy-propionic acid ethyl ester

HRID 1611973Notes

Reaction equation

HRID 1611973 reaction equation
[Cl:1][C:2]1[S:12][C:5]2[NH:6][C:7]([C:9](Cl)=[O:10])=[CH:8][C:4]=2[CH:3]=1.[CH2:13]([O:15][C:16](=[O:30])[C:17]([C:20]1[CH:21]=[N:22][C:23]([NH2:29])=[C:24]([O:26][CH2:27][CH3:28])[CH:25]=1)([OH:19])[CH3:18])[CH3:14]>>[CH2:13]([O:15][C:16](=[O:30])[C:17]([C:20]1[CH:21]=[N:22][C:23]([NH:29][C:9]([C:7]2[NH:6][C:5]3[S:12][C:2]([Cl:1])=[CH:3][C:4]=3[CH:8]=2)=[O:10])=[C:24]([O:26][CH2:27][CH3:28])[CH:25]=1)([OH:19])[CH3:18])[CH3:14]

Participants

3

Reactant 2

HCID 222527012-chloro-6H-thieno[2,3-b]pyrrole-5-carbonyl chlorideHCID 235938112-(6-Amino-5-ethoxy-pyridin-3-yl)-2-hydroxy-propionic acid ethyl ester

Product 1

HCID 695463622-{6-[(2-Chloro-6H-thieno[2,3-b]pyrrole-5-carbonyl)-amino]-5-ethoxy-pyridin-3-yl}-2-hydroxy-propionic acid ethyl ester

Procedure

The title compound was prepared from 2-chloro-6H-thieno[2,3-b]pyrrole-5-carbonyl chloride and 2-(6-amino-5-ethoxy-pyridin-3-yl)-2-hydroxy-propionic acid ethyl ester in a manner analogous to that described hereinabove in Example 2 using appropriate starting materials. LC/MS+=438.

Sources & evidence

ORD record
ord-c38d6b17cacc4351bbcb71cbd11c51bd
Source dataset
uspto-grants-2006_01
Patent number
US06992092B2

Reaction notes

Loading…