Hydrochloric Acid → HCID 11219431, compound

HRID 1611975Notes

Reaction equation

HRID 1611975 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:15]=[C:16]([O:20][CH3:21])[C:17]=1[O:18][CH3:19])[O:6][CH2:7][CH2:8][CH2:9][C:10]([O:12]CC)=[O:11].Cl>C(O)C.[OH-].[Na+]>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:15]=[C:16]([O:20][CH3:21])[C:17]=1[O:18][CH3:19])[O:6][CH2:7][CH2:8][CH2:9][C:10]([OH:12])=[O:11]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 11289513Ethyl 4-(3,4,5-trimethoxyphenoxy)butanoate

Product 1

HCID 11219431HCID 11219431, compound

Reagents, catalysts & solvents 2

HCID 702EthanolSolventHCID 14798Sodium HydroxideSolvent

Procedure

7 g of the compound obtained in Step A are stirred at room temperature for 72 hours in a mixture of 100 ml of ethanol and 100 ml of 1M aqueous sodium hydroxide solution. Having been rendered acidic by 100 ml of 1M hydrochloric acid, the reaction mixture is extracted with dichloromethane. The organic fractions are dried over sodium sulphate and evaporated under reduced pressure, enabling the expected product to be isolated.

Workup

  1. extractionthe reaction mixture is extracted with dichloromethane
  2. dry with materialThe organic fractions are dried over sodium sulphate
  3. customevaporated under reduced pressure
  4. customto be isolated

Sources & evidence

ORD record
ord-cc3b49bc821b40c0a3da02829477fb8a
Source dataset
uspto-grants-2006_01
Patent number
US06992085B2

Reaction notes

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