Acrylonitrile → (Octahydro-2H-pyrido[1,2-a]pyrazin-2-yl)acetonitrile

HRID 1611985Notes

Reaction equation

HRID 1611985 reaction equation
[CH2:1]1[NH:6][CH2:5][CH2:4][N:3]2[CH2:7][CH2:8][CH2:9][CH2:10][CH:2]12.[C:11](#[N:14])[CH:12]=C>C(#N)C>[CH2:1]1[N:6]([CH2:12][C:11]#[N:14])[CH2:5][CH2:4][N:3]2[CH2:7][CH2:8][CH2:9][CH2:10][CH:2]12

Participants

4

Reactant 2

HCID 7855AcrylonitrileHCID 2876391(+-)-1,4-Diazabicyclo[4.4.0]decane

Product 1

HCID 22252394(Octahydro-2H-pyrido[1,2-a]pyrazin-2-yl)acetonitrile

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

8 g of octahydro-2H-pyrido[1,2-a]pyrazine and 12 ml of acrylonitrile are refluxed for 48 hours in 150 ml of acetonitrile. The solvent is then removed in vacuo to yield 11 g of a pale yellow oil.

Workup

  1. customThe solvent is then removed in vacuo

Sources & evidence

ORD record
ord-2c99c4fb7b024d72afe317b09907e434
Source dataset
uspto-grants-2006_01
Patent number
US06992085B2

Reaction notes

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