Ethyl Acrylate → HCID 22252333, compound

HRID 1611989Notes

Reaction equation

HRID 1611989 reaction equation
[CH2:1]1[NH:6][CH2:5][CH2:4][N:3]2[CH2:7][CH2:8][CH2:9][CH2:10][CH:2]12.[C:11]([O:15][CH2:16][CH3:17])(=[O:14])[CH:12]=[CH2:13]>C(#N)C>[CH2:1]1[N:6]([CH2:13][CH2:12][C:11]([O:15][CH2:16][CH3:17])=[O:14])[CH2:5][CH2:4][N:3]2[CH2:7][CH2:8][CH2:9][CH2:10][CH:2]12

Participants

4

Reactant 2

HCID 8821Ethyl AcrylateHCID 2876391(+-)-1,4-Diazabicyclo[4.4.0]decane

Product 1

HCID 22252333HCID 22252333, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of 3.5 g of octahydro-2H-pyrido[1,2-a]pyrazine and 8 ml of ethyl acrylate in 50 ml of acetonitrile is refluxed for 24 hours. The solvent is removed in vacuo to yield the expected product.

Workup

  1. customThe solvent is removed in vacuo

Sources & evidence

ORD record
ord-613ffa746ba54f15967e273e7a0b8205
Source dataset
uspto-grants-2006_01
Patent number
US06992085B2

Reaction notes

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