Sodium Hydroxide → HCID 17934199, compound

HRID 1612019Notes

Reaction equation

HRID 1612019 reaction equation
[OH:1][C:2]1[C:3]([Se:16][C:17]2[CH:27]=[CH:26][C:20]([C:21]([O:23]CC)=[O:22])=[CH:19][N:18]=2)=[CH:4][C:5]2[C:6]([CH3:15])([CH3:14])[CH2:7][CH2:8][C:9]([CH3:13])([CH3:12])[C:10]=2[CH:11]=1.[OH-].[Na+]>C1COCC1.C(O)C>[OH:1][C:2]1[C:3]([Se:16][C:17]2[CH:27]=[CH:26][C:20]([C:21]([OH:23])=[O:22])=[CH:19][N:18]=2)=[CH:4][C:5]2[C:6]([CH3:15])([CH3:14])[CH2:7][CH2:8][C:9]([CH3:12])([CH3:13])[C:10]=2[CH:11]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 22252720HCID 22252720, compound

Product 1

HCID 17934199HCID 17934199, compound

Reagents, catalysts & solvents 1

HCID 21873804Tetrahydrofuran ethanolSolvent

Procedure

In a manner similar to that of Example 2, by reaction of 400 mg (0.92 mmol) of ethyl 6-(3-hydroxy-5,5,8,8-tetramethyl-5,6,7,8-tetrahydro-2-naphthylselanyl)nicotinate with 357 mg (8.9 mmol) of sodium hydroxide in a THF/ethanol mixture (20 ml/20 ml), 60 mg (16%) of a yellow powder are obtained. m.p.: 250° C.

Workup

  1. customare obtained

Sources & evidence

ORD record
ord-d872d90c2f3d4178922d042e48e31ebe
Source dataset
uspto-grants-2006_01
Patent number
US06992094B1

Reaction notes

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