6,7-Dihydro-5H-cyclopenta[b]pyridin-5-amine → cis-2-ethyl-6-methoxy-2,3-dihydro-1H-inden-1-amine

HRID 1612236Notes

Reaction equation

HRID 1612236 reaction equation
N1C=CC=C2C(N)CCC=12.[CH2:11]([CH:13]1[CH2:21][C:20]2[C:15](=[CH:16][C:17]([O:22][CH3:23])=[CH:18][CH:19]=2)[C:14]1=[N:24]O)[CH3:12]>>[CH2:11]([C@H:13]1[CH2:21][C:20]2[C:15](=[CH:16][C:17]([O:22][CH3:23])=[CH:18][CH:19]=2)[C@H:14]1[NH2:24])[CH3:12]

Participants

3

Reactant 2

HCID 221473916,7-Dihydro-5H-cyclopenta[b]pyridin-5-amineHCID 738670802-ethyl-6-methoxy-2,3-dihydro-1H-inden-1-one oxime

Product 1

HCID 68811220cis-2-ethyl-6-methoxy-2,3-dihydro-1H-inden-1-amine

Procedure

Following the procedure for the preparation of 6,7-dihydro-5H-cyclopenta[b]pyridin-5-amine but substituting 2-ethyl-6-methoxy-2,3-dihydro-1H-inden-1-one oxime and making non-critical variations provided the title compound as a oil: 1H NMR (CDCl3) δ 1.03, 1.39, 2.30, 2.63, 2.86, 3.82, 4.26, 6.77, 7.12;

Sources & evidence

ORD record
ord-45cc39577be948be9e5fa7a9f592f791
Source dataset
uspto-grants-2006_01
Patent number
US06992087B2

Reaction notes

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