5-Methoxyindan-1-one oxime → 5-methoxy-2,3-dihydro-1H-inden-1-amine

HRID 1612241Notes

Reaction equation

HRID 1612241 reaction equation
N1C=CC=C2C(N)CCC=12.[CH3:11][O:12][C:13]1[CH:14]=[C:15]2[C:19](=[CH:20][CH:21]=1)[C:18](=[N:22]O)[CH2:17][CH2:16]2>>[CH3:11][O:12][C:13]1[CH:14]=[C:15]2[C:19](=[CH:20][CH:21]=1)[CH:18]([NH2:22])[CH2:17][CH2:16]2

Participants

3

Reactant 2

HCID 2881895-Methoxyindan-1-one oximeHCID 221473916,7-Dihydro-5H-cyclopenta[b]pyridin-5-amine

Product 1

HCID 30167405-methoxy-2,3-dihydro-1H-inden-1-amine

Procedure

Following the procedure for the preparation of 6,7-dihydro-5H-cyclopenta[b]pyridin-5-amine but substituting 5-methoxyindan-1-one oxime and making non-critical variations provided the title compound as a oil: 1H NMR (CDCl3) δ 1.73, 2.75, 2.80, 2.94, 3.82, 4.34, 6.80, 7.25; HRMS (FAB) calcd for C10H11NO+H 162.0919, found 162.0922.

Sources & evidence

ORD record
ord-ff5eae21f77a43fbbedf54cb07cda22a
Source dataset
uspto-grants-2006_01
Patent number
US06992087B2

Reaction notes

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