Triphosgene → HCID 22253370, compound

HRID 1612386Notes

Reaction equation

[CH2:1]([CH:3]([NH:6][C:7]1[CH:12]=[C:11]([CH3:13])[N:10]=[C:9]([O:14][C:15]2[C:20]([CH3:21])=[CH:19][C:18]([CH3:22])=[CH:17][C:16]=2[CH3:23])[C:8]=1[OH:24])[CH2:4][CH3:5])[CH3:2].Cl[C:26](Cl)([O:28]C(=O)OC(Cl)(Cl)Cl)Cl>>[CH2:1]([CH:3]([N:6]1[C:7]2[CH:12]=[C:11]([CH3:13])[N:10]=[C:9]([O:14][C:15]3[C:20]([CH3:21])=[CH:19][C:18]([CH3:22])=[CH:17][C:16]=3[CH3:23])[C:8]=2[O:24][C:26]1=[O:28])[CH2:4][CH3:5])[CH3:2]

Participants

Reactant 2

HCID 94429Triphosgene

HCID 22052297HCID 22052297, compound

Product 1

HCID 22253370HCID 22253370, compound

Procedure

The title compound was prepared as a grey solid by the method analogous to that described in the Example 21 starting from 4-(1-Ethyl-propylamino)-6-methyl-2-(2,4,6-trimethyl-phenoxy)-pyridin-3-ol and triphosgene. 1H NMR (CDCl3) δ 6.87(s,2H), 6.55(s,1H), 3.98(m,1H), 2.29(s,3H), 2.28(s,3H), 2.09(s,6H), 1.9–2.05(m,2H), 1.8–1.9(m,2H), 0.90(t,6H) ppm.

Sources & evidence

ORD record: ord-47c09f6a3d3f4a3ba164993fec948538
Source dataset: uspto-grants-2006_01
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06992188B1

Reaction notes

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