HCID 69587003, compound → HCID 23594222, compound

HRID 1612404Notes

Reaction equation

HRID 1612404 reaction equation
Cl.Cl.[NH2:3][CH2:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][C:12]([N:14]([CH3:28])[C@@H:15]([C:22]2[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=2)[CH2:16][N:17]2[CH2:21][CH2:20][CH2:19][CH2:18]2)=[O:13])=[CH:7][CH:6]=1.Cl.Cl.NCC1C=CC=CC=1[CH2:39][C:40](N(C)[C@@H](C1C=CC=CC=1)CN1CCCC1)=[O:41]>>[C:40]([NH:3][CH2:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][C:12]([N:14]([CH3:28])[C@@H:15]([C:22]2[CH:23]=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH2:16][N:17]2[CH2:18][CH2:19][CH2:20][CH2:21]2)=[O:13])=[CH:7][CH:6]=1)(=[O:41])[CH3:39]

Participants

3

Reactant 2

HCID 69587003HCID 69587003, compoundHCID 69587683HCID 69587683, compound

Product 1

HCID 23594222HCID 23594222, compound

Procedure

Compound 9c was prepared by following the procedure of Example 7, Step h, except 8c was substituted for 8a. (87%) 1H NMR (400 MHz, CDCl3) δ 7.07-7.36 (m, 9H), 6.11 (m, 1H), 5.80 (m, 1H), 4.39 (m, 2H), 3.76 (m, 2H), 2.78-3.19 (m, 2H), 2.71 (s, 4H), 2.49 (m, 2H), 2.01 (m, 3H), 1.75 (m, 5H). Mass Spectral Analysis m/z=394.3. (M+H)+ tR=3.13 min (99%)

Sources & evidence

ORD record
ord-524d9f2910a24b1e815ea22b8233631c
Source dataset
uspto-grants-2006_01
Patent number
US06992193B2

Reaction notes

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