反应详情

A solution of 3,5-bis-(2-oxopyrrolidin-1-yl)benzoic acid methyl ester (D7) (201 mg, 0.666 mmol) in dioxane (2 ml) was treated with LiOH (42 mg, 0.998 mmol) and water (1 ml). The reaction mixture was stirred for 2 hours at room temperature. The solvent was then evaporated to dryness and the residue was partitioned between ethyl acetate and water. The aqueous layer was separated and acidified to pH=1. The product precipitated in the aqueous layer and was removed by filtration and dried in vacuo to D8 (128 mg) as white solid.

1. customThe solvent was then evaporated to dryness
2. customthe residue was partitioned between ethyl acetate and water
3. customThe aqueous layer was separated
4. customThe product precipitated in the aqueous layer
5. customwas removed by filtration
6. dry with materialdried in vacuo to D8 (128 mg) as white solid