反应详情

To 5-(2-oxopyrrolidin-1-yl)-biphenyl-3-carboxylic acid methyl ester (D10) (23 mg, 0.078 mmol) in dioxane (2 ml) was added LiOH (5 mg, 0.117 mmol) and water (1 ml) and stirred at room temperature for 2 hours. The solvent was then evaporated to dryness and the residue was partitioned between ethyl acetate and water. The aqueous layer was separated and acidified to pH=1. The product precipitated in the aqueous layer and was removed by filtration and dried in vacuo to afford D11 (10 mg) as white solid.

1. customThe solvent was then evaporated to dryness
2. customthe residue was partitioned between ethyl acetate and water
3. customThe aqueous layer was separated
4. customThe product precipitated in the aqueous layer
5. customwas removed by filtration
6. customdried in vacuo
7. customto afford D11 (10 mg) as white solid