反应详情

3-(2-Oxooxazolidin-3-yl)benzoic acid methyl ester (D118) (110 mg, 0.5 mmol) in dioxane (2.5 ml) was treated with 1M LiOH solution (0.75 ml) and the mixture was stirred at room temperature for 1.5 h. Amberlyst 15 was then added and stirring continued for 15 mins. The resin was filtered and the filtrate evaporated to dryness. Th residue was tritutated with diethyl ether to afford the title compound (62 mg, 60%).

1. additionAmberlyst 15 was then added
2. stirringstirring
3. waitcontinued for 15 mins
4. filtrationThe resin was filtered
5. customthe filtrate evaporated to dryness