2-Pyrrolidone → 2-Fluoro-3-(2-oxopyrrolidin-1-yl)benzoic Acid Methyl Ester

HRID 1612445Notes

Reaction equation

HRID 1612445 reaction equation
[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6](Br)[C:5]=1[F:11].[NH:13]1[CH2:17][CH2:16][CH2:15][C:14]1=[O:18]>>[CH3:1][O:2][C:3](=[O:12])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([N:13]2[CH2:17][CH2:16][CH2:15][C:14]2=[O:18])[C:5]=1[F:11]

Participants

3

Reactant 2

HCID 120252-PyrrolidoneHCID 21584505Methyl 3-bromo-2-fluorobenzoate

Product 1

HCID 695899492-Fluoro-3-(2-oxopyrrolidin-1-yl)benzoic Acid Methyl EsterYield 26.9%

Procedure

3-Bromo-2-fluorobenzoic acid methyl ester (500 mg, 2.15 mmol) was treated with pyrrolidin-2-one (273 mg, 3.22 mmol) as described in D24 to afford the title ester (137 mg).

Sources & evidence

ORD record
ord-97cff65f766e47318b9c8d09d638b1b5
Source dataset
uspto-grants-2006_01
Patent number
US06992103B2

Reaction notes

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