HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Pyrrolidone → 2-Fluoro-3-(2-oxopyrrolidin-1-yl)benzoic Acid Methyl Ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Pyrrolidone | HCID 12025 | — |
| Reactant | Methyl 3-bromo-2-fluorobenzoate | HCID 21584505 | — |
| Product | 2-Fluoro-3-(2-oxopyrrolidin-1-yl)benzoic Acid Methyl Ester | HCID 69589949 | 26.9% |
Reaction Steps
3-Bromo-2-fluorobenzoic acid methyl ester (500 mg, 2.15 mmol) was treated with pyrrolidin-2-one (273 mg, 3.22 mmol) as described in D24 to afford the title ester (137 mg).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06992103B2 |
| Source dataset | uspto-grants-2006_01 |
| ORD ID | ord-97cff65f766e47318b9c8d09d638b1b5 |
| Source note | uspto-grants-2006_01 |