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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1612446Generated: November 1, 2026

Lithium Hydroxide → 2-Fluoro-3-(2-oxopyrrolidin-1-yl)benzoic Acid

https://huagongshe.com/reaction/1612446

Reaction equation

Participants

RoleNameHCIDCharge
ReactantLithium HydroxideHCID 3939—
Reactant2-Fluoro-3-(2-oxopyrrolidin-1-yl)benzoic Acid Methyl EsterHCID 69589949—
Product2-Fluoro-3-(2-oxopyrrolidin-1-yl)benzoic AcidHCID 22252981—

Reaction Steps

2-Fluoro-3-(2-oxopyrrolidin-1-yl)benzoic acid methyl ester (D26) (137 mg, 0.58 mmol) was treated with 1M LiOH as described in D25 to afford D27 (85 mg, 66%).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06992103B2
Source datasetuspto-grants-2006_01
ORD IDord-c92ddf6e629a4cb8a234ba408f4bef2f
Source noteuspto-grants-2006_01