Lithium Hydroxide → 2-Fluoro-3-(2-oxopyrrolidin-1-yl)benzoic Acid

HRID 1612446Notes

Reaction equation

HRID 1612446 reaction equation
C[O:2][C:3](=[O:17])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([N:10]2[CH2:14][CH2:13][CH2:12][C:11]2=[O:15])[C:5]=1[F:16].[Li+].[OH-]>>[F:16][C:5]1[C:6]([N:10]2[CH2:14][CH2:13][CH2:12][C:11]2=[O:15])=[CH:7][CH:8]=[CH:9][C:4]=1[C:3]([OH:17])=[O:2]

Participants

3

Reactant 2

HCID 3939Lithium HydroxideHCID 695899492-Fluoro-3-(2-oxopyrrolidin-1-yl)benzoic Acid Methyl Ester

Product 1

HCID 222529812-Fluoro-3-(2-oxopyrrolidin-1-yl)benzoic Acid

Procedure

2-Fluoro-3-(2-oxopyrrolidin-1-yl)benzoic acid methyl ester (D26) (137 mg, 0.58 mmol) was treated with 1M LiOH as described in D25 to afford D27 (85 mg, 66%).

Workup

  1. customto afford D27 (85 mg, 66%)

Sources & evidence

ORD record
ord-c92ddf6e629a4cb8a234ba408f4bef2f
Source dataset
uspto-grants-2006_01
Patent number
US06992103B2

Reaction notes

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