反应详情

t-Butyl 2-methoxy-6-(2-oxopyrrolidin-1-yl)pyridine-4-carboxylate (D57) (0.27 g) was stirred overnight in a dioxan solution of HCl (4M; 10 mL). The solution was evaporated to dryness and dissolved in sat. aq. sodium bicarbonate. The basic aqueous solution was washed twice with ether and was then acidified to pH4 with citric acid solution (10% aq.), saturated with NaCl and extracted three times with ethyl acetate. The combined extracts were washed with brine, dried and evaporated to a solid which was triturated with water, collected by filtration and dried at 50° C. in vacuo (silica gel desiccant). The title compound (D58) was obtained as an off-white solid (0.141 g).

1. customThe solution was evaporated to dryness
2. dissolutiondissolved in sat. aq. sodium bicarbonate
3. washThe basic aqueous solution was washed twice with ether
4. extractionextracted three times with ethyl acetate
5. washThe combined extracts were washed with brine
6. customdried
7. customevaporated to a solid which
8. customwas triturated with water
9. filtrationcollected by filtration
10. customdried at 50° C. in vacuo (silica gel desiccant)