HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Allyloxy-N-[(1S,2S,4R)-1-benzyl-4-(3,3-dimethylbutylcarbamoyl)-2-hydroxypentyl]-5-(2-oxopyrrolidin-1-yl)-benzamide → N-[(1S,2S,4R)-1-Benzyl-4-(3,3-dimethylbutylcarbamoyl)-2-hydroxypentyl]-3-(2-oxopyrrolidin-1-yl)-5-propoxybenzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Allyloxy-N-[(1S,2S,4R)-1-benzyl-4-(3,3-dimethylbutylcarbamoyl)-2-hydroxypentyl]-5-(2-oxopyrrolidin-1-yl)-benzamide | HCID 10196598 | — |
| Catalyst | Palladium barium sulphate | HCID 17887766 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | N-[(1S,2S,4R)-1-Benzyl-4-(3,3-dimethylbutylcarbamoyl)-2-hydroxypentyl]-3-(2-oxopyrrolidin-1-yl)-5-propoxybenzamide | HCID 10175116 | — |
Reaction Steps
The allyl compound of E3 (0.042 g) was hydrogenated in methanol (5 ml) in the presence of 5% palladium-barium sulfate (0.020 g) for 3 hrs. The mixture was filtered through celite and evaporated to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06992103B2 |
| Source dataset | uspto-grants-2006_01 |
| ORD ID | ord-659d2d66b187454faa605bea58a570e5 |
| Source note | uspto-grants-2006_01 |