HuagongsheHuagongshe Chemistry Print Report · For research reference only
Caprolactam → N-[(1S,2S,4R)-1-Benzyl-4-(bicyclo[2.2.1]hept-2-ylcarbamoyl)-2-hydroxypentyl]-3-methoxy-5-(2-oxoazepan-1-yl)benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Caprolactam | HCID 7768 | — |
| Reactant | N-[(1S,2S,4R)-1-Benzyl-4-(3,3-dimethylbutylcarbamoyl)-2-hydroxypentyl]-4-fluoro-3-(2-oxopyrrolidin-1-yl)-benzamide | HCID 10152661 | — |
| Reactant | N-[(1S,2S,4R)-1-Benzyl-4-(3,3-dimethylbutylcarbamoyl)-2-hydroxypentyl]-3-bromo-5-methoxybenzamide | HCID 69589673 | — |
| Product | N-[(1S,2S,4R)-1-Benzyl-4-(bicyclo[2.2.1]hept-2-ylcarbamoyl)-2-hydroxypentyl]-3-methoxy-5-(2-oxoazepan-1-yl)benzamide | HCID 58583654 | — |
Reaction Steps
Prepared in an analogous manner to E1, from N-[(1S,2S,4R)-1-benzyl-4-(3,3-dimethylbutylcarbamoyl)-2-hydroxypentyl]-3-bromo-5-methoxybenzamide (D17) and ε-caprolactam.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06992103B2 |
| Source dataset | uspto-grants-2006_01 |
| ORD ID | ord-780a221d23654bc2819ca7f3726f09d9 |
| Source note | uspto-grants-2006_01 |