HRID1612491

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：C[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cc(-c2ccccc2)cc(N2CCCC2=O)c1)C(=O)NCCC(C)(C)C

HCID10129098

未命名化合物

HCID22253025

2-Fluoro-3-(2-oxo-1-pyrrolidinyl)-5-(trifluoromethyl)benzoic acid

C12H9F4NO3

结构：C[C@H](C[C@H](O)[C@@H](N)Cc1ccccc1)C(=O)NC1CC2CCC1C2

HCID68889549

未命名化合物

PRODUCTS

生成物

结构：C[C@H](C[C@H](O)[C@H](Cc1ccccc1)NC(=O)c1cc(C(F)(F)F)cc(N2CCCC2=O)c1F)C(=O)NC1CC2CCC1C2

HCID58583644

未命名化合物

PROCEDURE

实验过程

Prepared in an analogous manner to E6 from 2-fluoro-3-(2-oxopyrrolidin-1-yl)-5-trifluoromethyl benzoic acid (D25) and (2R,4S,5S)-5-amino-4-hydroxy-2-methyl-6-phenylhexanoic acid (bicyclo[2.2.1]hept-2-yl)amide (D29).

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-d1cdfd8c2e92410ea17c18cf0f04a3b3
来源数据集: uspto-grants-2006_01
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06992103B2
来源说明: uspto-grants-2006_01

反应 SMILES

C([C@H](NC(=O)C1C=C(C2C=CC=CC=2)C=C(N2CCCC2=O)C=1)[C@@H](O)C[C@H](C(=O)NCCC(C)(C)C)C)C1C=CC=CC=1.[F:44][C:45]1[C:53]([N:54]2[CH2:58][CH2:57][CH2:56][C:55]2=[O:59])=[CH:52][C:51]([C:60]([F:63])([F:62])[F:61])=[CH:50][C:46]=1[C:47]([OH:49])=O.[CH:64]12[CH2:70][CH:67]([CH2:68][CH2:69]1)[CH2:66][CH:65]2[NH:71][C:72](=[O:87])[C@H:73]([CH3:86])[CH2:74][C@H:75]([OH:85])[C@@H:76]([NH2:84])[CH2:77][C:78]1[CH:83]=[CH:82][CH:81]=[CH:80][CH:79]=1>>[CH2:77]([C@H:76]([NH:84][C:47](=[O:49])[C:46]1[CH:50]=[C:51]([C:60]([F:63])([F:62])[F:61])[CH:52]=[C:53]([N:54]2[CH2:58][CH2:57][CH2:56][C:55]2=[O:59])[C:45]=1[F:44])[C@@H:75]([OH:85])[CH2:74][C@H:73]([C:72](=[O:87])[NH:71][CH:65]1[CH2:66][CH:67]2[CH2:70][CH:64]1[CH2:69][CH2:68]2)[CH3:86])[C:78]1[CH:79]=[CH:80][CH:81]=[CH:82][CH:83]=1