HuagongsheHuagongshe Chemistry Print Report · For research reference only
N-[(1S,2S,4R)-1-Benzyl-4-(3,3-dimethylbutylcarbamoyl)-2-hydroxypentyl]-3-(2-oxopyrrolidin-1-yl)-5-phenylbenzamide → N-[(1S,2S,4R)-1-Benzyl-4-(bicyclo[2.2.1]hept-2-ylcarbamoyl)-2-hydroxypentyl]-2-fluoro-3-(2-oxopyrrolidin-1-yl)-5-trifluoromethyl-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | N-[(1S,2S,4R)-1-Benzyl-4-(3,3-dimethylbutylcarbamoyl)-2-hydroxypentyl]-3-(2-oxopyrrolidin-1-yl)-5-phenylbenzamide | HCID 10129098 | — |
| Reactant | 2-Fluoro-3-(2-oxopyrrolidin-1-yl)-5-trifluoromethyl Benzoic Acid | HCID 22253025 | — |
| Reactant | (2R,4S,5S)-5-Amino-4-hydroxy-2-methyl-6-phenylhexanoic acid (bicyclo[2.2.1]hept-2-yl)amide | HCID 68889549 | — |
| Product | N-[(1S,2S,4R)-1-Benzyl-4-(bicyclo[2.2.1]hept-2-ylcarbamoyl)-2-hydroxypentyl]-2-fluoro-3-(2-oxopyrrolidin-1-yl)-5-trifluoromethyl-benzamide | HCID 58583644 | — |
Reaction Steps
Prepared in an analogous manner to E6 from 2-fluoro-3-(2-oxopyrrolidin-1-yl)-5-trifluoromethyl benzoic acid (D25) and (2R,4S,5S)-5-amino-4-hydroxy-2-methyl-6-phenylhexanoic acid (bicyclo[2.2.1]hept-2-yl)amide (D29).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06992103B2 |
| Source dataset | uspto-grants-2006_01 |
| ORD ID | ord-d1cdfd8c2e92410ea17c18cf0f04a3b3 |
| Source note | uspto-grants-2006_01 |