Bromine → 2-(4-Bromo-3-oxobutyl)-1H-isoindole-1,3(2H)-dione

HRID 1612577Notes

Reaction equation

HRID 1612577 reaction equation
[C:1]1(=[O:16])[N:5]([CH2:6][CH2:7][C:8](=[O:10])[CH3:9])[C:4](=[O:11])[C:3]2=[CH:12][CH:13]=[CH:14][CH:15]=[C:2]12.[Br:17]Br>CO>[Br:17][CH2:9][C:8](=[O:10])[CH2:7][CH2:6][N:5]1[C:4](=[O:11])[C:3]2=[CH:12][CH:13]=[CH:14][CH:15]=[C:2]2[C:1]1=[O:16]

Participants

4

Reactant 2

HCID 24408BromineHCID 2907282-(3-Oxobutyl)isoindoline-1,3-dione

Product 1

HCID 37597442-(4-Bromo-3-oxobutyl)-1H-isoindole-1,3(2H)-dione

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a suspension of 130 g (0.6 mole) of 4-phthalimido butan-2-one (7a) in 1000 ml of absolute methanol is added 96 g (0.6 mole) of bromine and the reaction mixture is stirred for 24 hours at room temperature.

Sources & evidence

ORD record
ord-8676e1e96ec84919bf2d9781e97b28ca
Source dataset
uspto-grants-1993_03
Patent number
US05190589

Reaction notes

Loading…