HCID 9845489, compound → HCID 19776502, compound

Participants

Reaction Steps

To a suspension of 3-mercapto-6-methyl-4-[(2-oxoazacyclotridec-3 yl)aminocarbonyl]heptanoic acid, methyl ester (E2A) (1.03 g) in isopropanol (15 ml), previously purged with nitrogen, was added a solution of sodium hydroxide (0.29 g) in water (5 ml) and the resulting solution was stirred at room temperature, under nitrogen, for 18 h. The solution was acidified with an excess of ethereal-HCl and then evaporated to dryness in vacuo. The residue was treated with isopropanol and then evaporated to dryness in vacuo.

Provenance & Evidence