HCID 9845489, compound → HCID 19776502, compound

HRID 1612630Notes

Reaction equation

HRID 1612630 reaction equation
[SH:1][CH:2]([CH:8]([C:13]([NH:15][CH:16]1[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][CH2:19][NH:18][C:17]1=[O:29])=[O:14])[CH2:9][CH:10]([CH3:12])[CH3:11])[CH2:3][C:4]([O:6]C)=[O:5]>C(O)(C)C>[SH:1][CH:2]([CH:8]([C:13]([NH:15][CH:16]1[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][CH2:20][CH2:19][NH:18][C:17]1=[O:29])=[O:14])[CH2:9][CH:10]([CH3:12])[CH3:11])[CH2:3][C:4]([OH:6])=[O:5]

Participants

3

Reactant 1

HCID 9845489HCID 9845489, compound

Product 1

HCID 19776502HCID 19776502, compound

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

To a suspension of 3-mercapto-6-methyl-4-[(2-oxoazacyclotridec-3 yl)aminocarbonyl]heptanoic acid, methyl ester (E2A) (1.03 g) in isopropanol (15 ml), previously purged with nitrogen, was added a solution of sodium hydroxide (0.29 g) in water (5 ml) and the resulting solution was stirred at room temperature, under nitrogen, for 18 h. The solution was acidified with an excess of ethereal-HCl and then evaporated to dryness in vacuo. The residue was treated with isopropanol and then evaporated to dryness in vacuo.

Workup

  1. custompreviously purged with nitrogen
  2. additionwas added a solution of sodium hydroxide (0.29 g) in water (5 ml)
  3. customevaporated to dryness in vacuo
  4. additionThe residue was treated with isopropanol
  5. customevaporated to dryness in vacuo

Sources & evidence

ORD record
ord-e5820b52ce974954a63dc1e1fd1b391d
Source dataset
uspto-grants-1993_03
Patent number
US05190937

Reaction notes

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