HCID 54000078, compound → HCID 54126786, compound

HRID 1612645Notes

Reaction equation

HRID 1612645 reaction equation
[CH3:1][O:2][C:3](=[S:19])[C:4]1[CH:9]=[C:8]([N+:10]([O-])=O)[CH:7]=[C:6]([N+:13]([O-])=O)[C:5]=1[CH:16]([CH3:18])[CH3:17]>O1CCCC1.[Ni]>[CH3:1][O:2][C:3](=[S:19])[C:4]1[CH:9]=[C:8]([NH2:10])[CH:7]=[C:6]([NH2:13])[C:5]=1[CH:16]([CH3:17])[CH3:18]

Participants

4

Reactant 1

HCID 54000078HCID 54000078, compound

Product 1

HCID 54126786HCID 54126786, compound

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 8028TetrahydrofuranSolvent

Procedure

26.6 g (0.0886 mol) of 3,5-dinitro-2-isopropylthiobenzoic acid methyl ester are dissolved in 270 ml of tetrahydrofuran and hydrogenated with the addition of 10 g of Raney nickel at from 30° to 35° C. The catalyst is then isolated by filtration, the filtrate is concentrated and the residue is crystallised from ethyl acetate/hexane.

Workup

  1. customThe catalyst is then isolated by filtration
  2. concentrationthe filtrate is concentrated
  3. customthe residue is crystallised from ethyl acetate/hexane

Sources & evidence

ORD record
ord-596f190f88e34965ac89a107ebdda8a7
Source dataset
uspto-grants-1993_03
Patent number
US05190928

Reaction notes

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