HCID 19090881, compound → HCID 9920471, compound

HRID 1612673Notes

Reaction equation

HRID 1612673 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][P:5]([CH2:11][CH2:12][CH3:13])(=[O:10])[O:6]C(C)C>Cl>[NH2:1][CH2:2][CH2:3][CH2:4][P:5]([CH2:11][CH2:12][CH3:13])(=[O:6])[OH:10]

Participants

3

Reactant 1

HCID 19090881HCID 19090881, compound

Product 1

HCID 9920471HCID 9920471, compound

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

7.0 g of isopropyl 3-aminopropyl(n-propyl)phosphinate and 40 ml of 20% hydrochloric acid are stirred at reflux temperature overnight. The reaction mixture is evaporated to dryness, taken up in methanol and treated with propylene oxide. The white solid is filtered off and dried over phosphorous pentoxide to yield 3-aminopropyl(n-propyl)phosphinic acid×0.1 H2O as white crystals, m.p. 210°-213°.

Workup

  1. temperatureat reflux temperature overnight
  2. customThe reaction mixture is evaporated to dryness
  3. additiontreated with propylene oxide
  4. filtrationThe white solid is filtered off
  5. dry with materialdried over phosphorous pentoxide

Sources & evidence

ORD record
ord-9ee457231016470fa0e361f33bbc5862
Source dataset
uspto-grants-1993_03
Patent number
US05190933

Reaction notes

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