Hydrochloric Acid → HCID 9815542, compound

HRID 1612701Notes

Reaction equation

HRID 1612701 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][P:5]([CH:10]([OH:14])[CH2:11][CH2:12][CH3:13])(=[O:9])[O:6]CC.Cl>>[NH2:1][CH2:2][CH2:3][CH2:4][P:5]([CH:10]([OH:14])[CH2:11][CH2:12][CH3:13])(=[O:6])[OH:9]

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 19090868HCID 19090868, compound

Product 1

HCID 9815542HCID 9815542, compoundYield 85.8%

Procedure

A mixture of 2.0 g ethyl 3-aminopropyl(1-hydroxybutyl)-phosphinate and 20.0 ml 2M aqueous hydrochloric acid is refluxed for 2 hours and then evaporated to dryness. The residual oil is dissolved in 10 ml of water, and re-evaporated. The residue is dissolved in 20 ml of ethanol and treated with propylene oxide and to give 1.5 g of 3-aminopropyl(1-hydroxybutyl)phosphinic acid, m.p. 188°.

Workup

  1. temperatureis refluxed for 2 hours
  2. customevaporated to dryness
  3. dissolutionThe residual oil is dissolved in 10 ml of water
  4. customre-evaporated
  5. dissolutionThe residue is dissolved in 20 ml of ethanol
  6. additiontreated with propylene oxide

Sources & evidence

ORD record
ord-af6f8b30ed934f5fbcc43e6d32cfe648
Source dataset
uspto-grants-1993_03
Patent number
US05190933

Reaction notes

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