Dimethylformamide → 6-bromo-2-(2-fluorobenzyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic Acid Methyl Ester

HRID 161271Notes

Reaction equation

HRID 161271 reaction equation
[C:32]([N:33]=[P:34]1([N:35]([CH2:36][CH3:37])[CH2:38][CH3:39])[N:40]([CH3:41])[CH2:42][CH2:43][CH2:44][N:45]1[CH3:46])([CH3:47])([CH3:48])[CH3:49].[CH3:1][O:2][C:3](=[O:4])[c:5]1[nH:6][c:7](=[O:22])[c:8]2[cH:9][cH:10][c:11]([Br:21])[cH:12][c:13]2[c:14]1-[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1.[CH3:50][N:51]([CH3:52])[CH:53]=[O:54].[F:23][c:24]1[c:25]([CH2:26][Br:27])[cH:28][cH:29][cH:30][cH:31]1>>[CH3:1][O:2][C:3](=[O:4])[c:5]1[n:6]([CH2:26][c:25]2[c:24]([F:23])[cH:31][cH:30][cH:29][cH:28]2)[c:7](=[O:22])[c:8]2[cH:9][cH:10][c:11]([Br:21])[cH:12][c:13]2[c:14]1-[c:15]1[cH:16][cH:17][cH:18][cH:19][cH:20]1

Participants

5

Reactant 4

HCID 6228DimethylformamideHCID 67968alpha-Bromo-o-fluorotolueneHCID 35138512-((1,1-Dimethylethyl)imino)-N,N-diethylhexahydro-1,3-dimethyl-2lambda5-1,3,2-diazaphosphorin-2-amineHCID 691573826-bromo-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic Acid Methyl Ester

Product 1

HCID 691563726-bromo-2-(2-fluorobenzyl)-1-oxo-4-phenyl-1,2-dihydroisoquinoline-3-carboxylic Acid Methyl Ester

Sources & evidence

ORD record
ord-1dff398002794dc29605f29fab14a351
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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