Water → {1-Azabicyclo[3.3.1]nonan-5-yl}methanamine

HRID 1612734노트

반응식

HRID 1612734 반응식
[N:1]12[CH2:9][C:5]([C:10]([NH2:12])=O)([CH2:6][CH2:7][CH2:8]1)[CH2:4][CH2:3][CH2:2]2.[H-].[Al+3].[Li+].[H-].[H-].[H-].O1CCCC1.O.[OH-].[Na+]>O1CCCC1.CCOCC>[N:1]12[CH2:9][C:5]([CH2:10][NH2:12])([CH2:6][CH2:7][CH2:8]1)[CH2:4][CH2:3][CH2:2]2

참가 물질

7

반응물 4

HCID 962Water2회HCID 14798Sodium HydroxideHCID 197959811-Azabicyclo[3.3.1]nonane-5-carboxamideHCID 68718528lithium aluminium hydride THF

생성물 1

HCID 19795986{1-Azabicyclo[3.3.1]nonan-5-yl}methanamine수율 77%

시약·촉매·용매 2

HCID 3283Diethyl Ether용매HCID 8028Tetrahydrofuran용매

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온도
0 °C

실험 절차

A suspension of 1-azabicyclo[3.3.1]nonane-5-carboxamide (1.80 g, 10.7 mmol) in anhydrous tetrahydrofuran (10 mL) under nitrogen was treated (via syringe) with 1.0 N lithium aluminum hydride/tetrahydrofuran (25 mL, 25 mmol),and the mixture was refluxed for 4 hours and cooled (0° C.). The mixture was treated carefully dropwise sequentially with water (1 mL), 15% sodium hydroxide (1 mL), and water (3 mL). Ether (50 mL) was added, the mixture was filtered through Celite, and the filter cake was washed with ether. The filtrate was concentrated in vacuo to afford 1.27 g (77%) of colorless oil.

후처리

  1. temperaturethe mixture was refluxed for 4 hours
  2. filtrationthe mixture was filtered through Celite
  3. washthe filter cake was washed with ether
  4. concentrationThe filtrate was concentrated in vacuo

출처 및 근거

ORD 기록
ord-ceeadb90dc8c4d598c3f39568b6d7d26
출처 데이터셋
uspto-grants-1993_03
특허 번호
US05190953

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