Tetrahydrofuran → tert-Butyl 3-(5-chloro-2-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)phenyl)-3-oxopropyl(methyl)carbamate

HRID 161274Notes

Reaction equation

HRID 161274 reaction equation
[CH2:16]([Li:17])[CH2:18][CH2:19][CH3:20].[CH2:38]1[O:39][CH2:40][CH2:41][CH2:42]1.[CH3:21][O:22][N:23]([C:24]([CH2:25][CH2:26][N:27]([C:28]([O:29][C:30]([CH3:31])([CH3:32])[CH3:33])=[O:34])[CH3:35])=[O:36])[CH3:37].[Cl:1][c:2]1[cH:3][c:4]([I:15])[c:5]([C:8]2=[N:12][C:11]([CH3:13])([CH3:14])[CH2:10][O:9]2)[cH:6][cH:7]1>>[Cl:1][c:2]1[cH:3][c:4]([C:24]([CH2:25][CH2:26][N:27]([C:28]([O:29][C:30]([CH3:31])([CH3:32])[CH3:33])=[O:34])[CH3:35])=[O:36])[c:5]([C:8]2=[N:12][C:11]([CH3:13])([CH3:14])[CH2:10][O:9]2)[cH:6][cH:7]1

Participants

5

Reactant 4

HCID 8028TetrahydrofuranHCID 122201312-(4-Chloro-2-iodophenyl)-4,4-dimethyl-4,5-dihydrooxazoleHCID 59364357Tert-butyl 3-(methoxy(methyl)amino)-3-oxopropyl(methyl)carbamateHCID 178418339Butyllithium

Product 1

HCID 59364350tert-Butyl 3-(5-chloro-2-(4,4-dimethyl-4,5-dihydrooxazol-2-yl)phenyl)-3-oxopropyl(methyl)carbamate

Sources & evidence

ORD record
ord-f33516f6efd54b3d8ace1123426b0385
Source dataset
Training data from https://doi.org/10.1039/C8SC04228D (9/10)

Reaction notes

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