Hydrochloric Acid → HCID 19776806, compound

HRID 1612816Notes

Reaction equation

HRID 1612816 reaction equation
[C:1]1([CH:7]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[O:8][CH:9]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][O:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[NH:25][S:26]([CH3:29])(=[O:28])=[O:27])[CH2:11][CH2:10]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:36]>C(O)C>[ClH:36].[C:1]1([CH:7]([C:30]2[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=2)[O:8][CH:9]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][O:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[NH:25][S:26]([CH3:29])(=[O:28])=[O:27])[CH2:11][CH2:10]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 19776730HCID 19776730, compound

Product 1

HCID 19776806HCID 19776806, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Into 20 ml of ethanol was dissolved 0.50 g of 4-diphenylmethoxy-1-[3-(2-methanesulfonylaminophenoxy)propyl]piperidine obtained in Example 1 (c), and 0.13 ml of 36% HCl was added dropwise to the resultant solution with cooling and stirring. The mixture was dried under reduced pressure to form a solid. The residue was recrystallized from isopropyl alcohol to give 0.43 g of the desired compound.

Workup

  1. temperaturewith cooling
  2. customThe mixture was dried under reduced pressure
  3. customto form a solid
  4. customThe residue was recrystallized from isopropyl alcohol

Sources & evidence

ORD record
ord-e8a24a61fbb840ec8fd09e80cd4179fb
Source dataset
uspto-grants-1993_03
Patent number
US05190959

Reaction notes

Loading…