Fumaric Acid → HCID 19776795, compound

HRID 1612817Notes

Reaction equation

HRID 1612817 reaction equation
[C:1]1([CH:7]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[O:8][CH:9]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][O:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[NH:25][S:26]([CH3:29])(=[O:28])=[O:27])[CH2:11][CH2:10]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:36]([OH:43])(=[O:42])/[CH:37]=[CH:38]/[C:39]([OH:41])=[O:40]>C(O)C>[C:36]([OH:43])(=[O:42])/[CH:37]=[CH:38]/[C:39]([OH:41])=[O:40].[C:1]1([CH:7]([C:30]2[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=2)[O:8][CH:9]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][O:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[NH:25][S:26]([CH3:29])(=[O:28])=[O:27])[CH2:11][CH2:10]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 444972Fumaric AcidHCID 19776730HCID 19776730, compound

Product 1

HCID 19776795HCID 19776795, compoundYield 79.6%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Into 40 ml of ethanol were dissolved at first 1.0 g of 4-diphenylmethoxy-1-[3-(2-methanesulfonylaminophenoxy)propyl]-piperidine obtained in Example 1 (c) and then 0.234 g of fumaric acid. The mixture was dried under reduced pressure to form a solid. The residue was recrystallized from isopropyl alcohol to give 0.98 g of the desired compound.

Workup

  1. customThe mixture was dried under reduced pressure
  2. customto form a solid
  3. customThe residue was recrystallized from isopropyl alcohol

Sources & evidence

ORD record
ord-97ec9733be744922a5742f867efb16d3
Source dataset
uspto-grants-1993_03
Patent number
US05190959

Reaction notes

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