Ethanesulfonyl chloride → HCID 19776742, compound

HRID 1612818Notes

Reaction equation

HRID 1612818 reaction equation
[C:1]1([CH:7]([C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)[O:8][CH:9]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][O:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[NH:25][S:26]([CH3:29])(=[O:28])=[O:27])[CH2:11][CH2:10]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:36]1(C(C2C=CC=CC=2)OC2CCN(CCCOC3C=CC=CC=3N)CC2)C=CC=CC=1.C(S(Cl)(=O)=O)C.CS(Cl)(=O)=O>>[C:1]1([CH:7]([C:30]2[CH:31]=[CH:32][CH:33]=[CH:34][CH:35]=2)[O:8][CH:9]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][O:18][C:19]3[CH:24]=[CH:23][CH:22]=[CH:21][C:20]=3[NH:25][S:26]([CH2:29][CH3:36])(=[O:28])=[O:27])[CH2:11][CH2:10]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 4

HCID 11667Ethanesulfonyl chlorideHCID 31297Methanesulfonyl chlorideHCID 19776730HCID 19776730, compoundHCID 19776753HCID 19776753, compound

Product 1

HCID 19776742HCID 19776742, compound

Procedure

The procedure of Example 1 (c) was repeated except for using 4-diphenylmethoxy-1-[3-(2-aminophenoxy)propyl]piperidine obtained in Example 1 (b) and ethanesulfonyl chloride instead of 4-diphenylmethoxy-1-[3-(2-aminophenoxy)propyl]piperidine and methanesulfonyl chloride to give the desired compound.

Sources & evidence

ORD record
ord-04c9d3aa199d4a56bd74cab2a89278a3
Source dataset
uspto-grants-1993_03
Patent number
US05190959

Reaction notes

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