HCID 19776700, compound → HCID 19776701, compound

HRID 1612845Notes

Reaction equation

HRID 1612845 reaction equation
Cl.[C:2]1([CH:8]([C:29]2[S:30][CH:31]=[CH:32][CH:33]=2)[O:9][CH:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][O:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[N+:26]([O-:28])=[O:27])[CH2:12][CH2:11]2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(=O)([O-])[O-].[Na+].[Na+]>[C:2]1([CH:8]([C:29]2[S:30][CH:31]=[CH:32][CH:33]=2)[O:9][CH:10]2[CH2:11][CH2:12][N:13]([CH2:16][CH2:17][CH2:18][O:19][C:20]3[CH:25]=[CH:24][CH:23]=[CH:22][C:21]=3[N+:26]([O-:28])=[O:27])[CH2:14][CH2:15]2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

3

Reactant 1

HCID 19776700HCID 19776700, compound

Product 1

HCID 19776701HCID 19776701, compoundYield 89.7%

Reagents, catalysts & solvents 1

HCID 10340Sodium CarbonateSolvent

Procedure

In 20 ml of 5% aqueous sodium carbonate solution was suspended 1.0 g of the hydrochloride obtained in the above. The resultant solution was extracted with ethyl acetate and the organic layer was washed with water. The solvent was removed under reduced pressure to give 0.83 g of oily 4-(phenyl-2-thienylmethoxy)-1-[3-(2-nitrophenoxy)propyl]piperidine.

Workup

  1. customobtained in the above
  2. extractionThe resultant solution was extracted with ethyl acetate
  3. washthe organic layer was washed with water
  4. customThe solvent was removed under reduced pressure

Sources & evidence

ORD record
ord-9dbb9f56fb9241d1ae87ec2b951c7ee4
Source dataset
uspto-grants-1993_03
Patent number
US05190959

Reaction notes

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