Phenyl-2-thienylmethyl chloride → 4-(Phenyl-2-thienylmethoxy)-1-[3-(2-nitrophenoxy)-3-methylpropyl]piperidine

HRID 1612847Notes

Reaction equation

HRID 1612847 reaction equation
[C:1]1([CH:7](Cl)[C:8]2[S:9][CH:10]=[CH:11][CH:12]=2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[OH:14][CH:15]1[CH2:20][CH2:19][N:18]([CH2:21][CH2:22][CH:23]([CH3:34])[O:24][C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=2[N+:31]([O-:33])=[O:32])[CH2:17][CH2:16]1.OC1CCN(CCCOC2C=CC=CC=2[N+]([O-])=O)CC1>>[C:1]1([CH:7]([C:8]2[S:9][CH:10]=[CH:11][CH:12]=2)[O:14][CH:15]2[CH2:16][CH2:17][N:18]([CH2:21][CH2:22][CH:23]([O:24][C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=3[N+:31]([O-:33])=[O:32])[CH3:34])[CH2:19][CH2:20]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 3

HCID 10512583Phenyl-2-thienylmethyl chlorideHCID 197767154-Hydroxy-1-[3-methyl-3-(2-nitrophenoxy)propyl]piperidineHCID 197767934-Hydroxy-1-[3-(2-nitrophenoxy)propyl]piperidine

Product 1

HCID 197768134-(Phenyl-2-thienylmethoxy)-1-[3-(2-nitrophenoxy)-3-methylpropyl]piperidine

Procedure

The procedure of Example 36 (a) was repeated except for using phenyl-2-thienylmethyl chloride and 4-hydroxy-1-[3-methyl-3-(2-nitrophenoxy)propyl]piperidine instead of phenyl-2-thienylmethyl chloride and 4-hydroxy-1-[3-(2-nitrophenoxy)propyl]piperidine to give oily 4-(phenyl-2-thienylmethoxy)-1-[3-(2-nitrophenoxy)-3-methylpropyl]piperidine.

Sources & evidence

ORD record
ord-8adb53932d094f3faceb00ba667ba1aa
Source dataset
uspto-grants-1993_03
Patent number
US05190959

Reaction notes

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