Water → N-(2,3-Dihydro-1H-inden-2-yl)formamide

HRID 1612892Notes

Reaction equation

HRID 1612892 reaction equation
[NH2:1][CH:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3]1.[C:11](O)(=[O:13])C.C(OC=O)=O.O>O1CCCC1>[CH:11]([NH:1][CH:2]1[CH2:10][C:9]2[C:4](=[CH:5][CH:6]=[CH:7][CH:8]=2)[CH2:3]1)=[O:13]

Participants

5

Reactant 3

HCID 962WaterHCID 763102-AminoindaneHCID 86740153HCID 86740153, compound

Product 1

HCID 14835235N-(2,3-Dihydro-1H-inden-2-yl)formamide

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent2×

Procedure

To a solution of 2-aminoindan (19.95 g) in tetrahydrofuran is added an solution of 2M acetic acid-formic acid anhydride in tetrahydrofuran under ice cooling, and the mixture is reacted at room temperature. To the reaction mixture is added water, and then, the solvent is distilled off, and the residue is extracted with ethyl acetate. After distilling off the solvent, the residue is recrystallized from ethyl acetate - n-hexane to give 2-formylaminoindan (19.02 g).

Workup

  1. customthe mixture is reacted at room temperature
  2. distillationthe solvent is distilled off
  3. extractionthe residue is extracted with ethyl acetate
  4. distillationAfter distilling off the solvent
  5. customthe residue is recrystallized from ethyl acetate - n-hexane

Sources & evidence

ORD record
ord-ac733324afe24761bce9d742b143df13
Source dataset
uspto-grants-1993_03
Patent number
US05190975

Reaction notes

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