Pyridine → HCID 67884295, compound

HRID 1612900Notes

Reaction equation

HRID 1612900 reaction equation
[C:1]1([CH:7]([CH2:33][CH3:34])[C:8]([O:10][CH2:11][CH2:12][N:13]2[CH2:18][CH2:17][N:16]([C:19](=[O:32])[C:20]3[CH:25]=[C:24]([O:26][CH3:27])[C:23]([O:28][CH3:29])=[C:22]([O:30][CH3:31])[CH:21]=3)[CH2:15][CH2:14]2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.N1C=CC=CC=1.C(Cl)(Cl)[Cl:42].C1(C(CC)C(Cl)=O)C=CC=CC=1>>[ClH:42].[C:1]1([CH:7]([CH2:33][CH3:34])[C:8]([O:10][CH2:11][CH2:12][N:13]2[CH2:14][CH2:15][N:16]([C:19](=[O:32])[C:20]3[CH:21]=[C:22]([O:30][CH3:31])[C:23]([O:28][CH3:29])=[C:24]([O:26][CH3:27])[CH:25]=3)[CH2:17][CH2:18]2)=[O:9])[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

5

Reactant 4

HCID 1049PyridineHCID 6212ChloroformHCID 981732-Phenylbutyryl chlorideHCID 54030030HCID 54030030, compound

Product 1

HCID 67884295HCID 67884295, compound

Procedure

To a solution of 16.2 g (0.05 mole) of N-[2-(2-phenyl-2-ethylacetoxy)ethyl]-N'-(3,4,5-trimethoxybenzoyl)piperazine and 4.75 g (0.06 mole) of pyridine in 50 ml of anhydrous chloroform 10.0 g (0.055 mole) of 2-phenyl-2-ethylacetyl chloride were added dropwise. The reaction mixture, treated as described in Example 1 yield the title product. M.p. 207° C. (ethanol).

Workup

  1. additionThe reaction mixture, treated

Sources & evidence

ORD record
ord-6df95f449c104751bb14f4b3153f785a
Source dataset
uspto-grants-1993_03
Patent number
US05190946

Reaction notes

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