Hydrochloric Acid → 2-(Methoxymethyl)morpholine hydrochloride

HRID 1612957Notes

Reaction equation

C([N:8]1[CH2:13][CH2:12][O:11][CH:10]([CH2:14][O:15][CH3:16])[CH2:9]1)C1C=CC=CC=1.C(O)C.[ClH:20]>>[ClH:20].[CH3:16][O:15][CH2:14][CH:10]1[O:11][CH2:12][CH2:13][NH:8][CH2:9]1

Participants

Reactant 3

HCID 313Hydrochloric Acid

HCID 702Ethanol

HCID 103534614-Benzyl-2-(methoxymethyl)morpholine

Product 1

HCID 197772332-(Methoxymethyl)morpholine hydrochloride

Procedure

N-Benzyl-2-methoxymethylmorpholine is subjected to hydrogenolysis in hydrogen chloride-containing ethanol in the same manner as described in Reference Example 15 to give 2-methoxymethylmorpholine hydrochloride.

Sources & evidence

ORD record: ord-d489419be23a4d48a4afe2f4a464e1b1
Source dataset: uspto-grants-1993_03
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05191079

Reaction notes

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