HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → 4-methyl-2,7-diphenyl-1H-pyrazolo[3,4-b]pyridine-3,6-dione
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Ethyl Acetoacetate | HCID 8868 | — |
| Reactant | HCID 178516394 | HCID 178516394 | — |
| Solvent | Water | HCID 962 | — |
| Product | 4-methyl-2,7-diphenyl-1H-pyrazolo[3,4-b]pyridine-3,6-dione | HCID 360316 | 34.5% |
Reaction Steps
25 g of 1-phenyl-3-anilino-2-pyrazoline-5-one, 180 g of ethyl acetoacetate, and 150 ml of acetic acid were heated while refluxing for 6 hours. The reaction solution was diluted with water, and the solid formed was crystallized from acetonitrile to obtain 10.9 g of 2,7-diphenyl-4-methylpyrazolo[3,4-b]pyridine-3,6-dione. Melting point: 145° to 147° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05192738 |
| Source dataset | uspto-grants-1993_03 |
| ORD ID | ord-3d88fcac97574307b1bbc025b352c071 |
| Source note | uspto-grants-1993_03 |