Phosphorus oxychloride → HCID 19775370, compound

HRID 1613154Notes

Reaction equation

HRID 1613154 reaction equation
O[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]([CH2:12][CH2:13][CH3:14])[C:4](=[O:15])[C:3]=1[C:16]#[N:17].P(Cl)(Cl)([Cl:20])=O>>[Cl:20][C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[N:5]([CH2:12][CH2:13][CH3:14])[C:4](=[O:15])[C:3]=1[C:16]#[N:17]

Participants

3

Reactant 2

HCID 24813Phosphorus oxychlorideHCID 54711049HCID 54711049, compound

Product 1

HCID 19775370HCID 19775370, compoundYield 41%

Procedure

In 10 ml of phosphorus oxychloride was refluxed 1.0 g (4.1 mmol) of 1,2-dihydro-4-hydroxy-1-propyl-2-oxo-3-quinolinecarbonitrile for 1 hour. The reaction mixture was dried under reduced pressure, and the residue was partitioned between chloroform and water. The chloroform layer was dried under reduced pressure to obtain 0.44 g (41%) of the titled compound as a yellow crystal.

Workup

  1. customThe reaction mixture was dried under reduced pressure
  2. customthe residue was partitioned between chloroform and water
  3. dry with materialThe chloroform layer was dried under reduced pressure

Sources & evidence

ORD record
ord-73184ec10802456cbde3162bb1dfbd1c
Source dataset
uspto-grants-1993_03
Patent number
US05192768

Reaction notes

Loading…