Chloroform → HCID 19775455, compound

HRID 1613170Notes

Reaction equation

HRID 1613170 reaction equation
[N:1]1([CH2:7][C:8]2[CH:9]=[C:10]([CH:16]=[CH:17][CH:18]=2)[O:11][CH2:12][CH2:13][CH2:14][NH2:15])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C[C:20](C)([C:24]([O-:26])=[O:25])[C:21]([O-:23])=O.[CH:28](Cl)(Cl)Cl>CO>[N:1]1([CH2:7][C:8]2[CH:9]=[C:10]([CH:16]=[CH:17][CH:18]=2)[O:11][CH2:12][CH2:13][CH2:14][NH:15][C:21](=[O:23])[CH2:20][C:24]([O:26][CH3:28])=[O:25])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

5

Reactant 3

HCID 6212ChloroformHCID 6946994DimethylmalonatHCID 102205613-(3-(Piperidin-1-ylmethyl)phenoxy)propan-1-amine

Product 1

HCID 19775455HCID 19775455, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
130 °C

Procedure

2.47 g of [3-[3-(piperidinomethyl)phenoxy]propylamine was dissolved n 40 ml of dimethylmalonate and stirred at external temperature of 130° C. for 2 hours. Then, an excessive quantity of dimethylmalonate was distilled of under reduced pressure. Light brown oily substance was obtained. The obtained substance was subjected to silica gel column chromatography (solvent; chloroform:methanol=6:1). As a result, 3.06 g of oily N-[3-[3-(piperidinomethyl)phenoxy]propyl]-2-methoxycarbonylacetamide was obtained.

Workup

  1. distillationThen, an excessive quantity of dimethylmalonate was distilled of under reduced pressure
  2. customLight brown oily substance was obtained

Sources & evidence

ORD record
ord-4342f12dce5847e5a9b59be75a83eb63
Source dataset
uspto-grants-1993_03
Patent number
US05192774

Reaction notes

Loading…