Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Chloroform | HCID 6212 | — |
| Reactant | Dimethylmalonat | HCID 6946994 | — |
| Reactant | 3-(3-(Piperidin-1-ylmethyl)phenoxy)propan-1-amine | HCID 10220561 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | HCID 19775455 | HCID 19775455 | — |
Reaction Steps
2.47 g of [3-[3-(piperidinomethyl)phenoxy]propylamine was dissolved n 40 ml of dimethylmalonate and stirred at external temperature of 130° C. for 2 hours. Then, an excessive quantity of dimethylmalonate was distilled of under reduced pressure. Light brown oily substance was obtained. The obtained substance was subjected to silica gel column chromatography (solvent; chloroform:methanol=6:1). As a result, 3.06 g of oily N-[3-[3-(piperidinomethyl)phenoxy]propyl]-2-methoxycarbonylacetamide was obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US05192774 |
|---|
| Source dataset | uspto-grants-1993_03 |
|---|
| ORD ID | ord-4342f12dce5847e5a9b59be75a83eb63 |
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| Source note | uspto-grants-1993_03 |
|---|
