1-Diphenylmethoxymethyl-1-(4-methoxyphenethylamino)cyclohexane → 1-Diphenylmethoxymethyl-1-[N-(4-methoxyphenethyl)-N-methylamino]-cyclohexane

HRID 1613175Notes

Reaction equation

HRID 1613175 reaction equation
[C:1]1([CH:7]([C:27]2[CH:32]=[CH:31][CH:30]=[CH:29][CH:28]=2)[O:8][CH2:9][C:10]2([NH:16][CH2:17][CH2:18][C:19]3[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][CH:20]=3)[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[C:33]([BH3-])#N.[Na+].C=O>>[C:27]1([CH:7]([C:1]2[CH:2]=[CH:3][CH:4]=[CH:5][CH:6]=2)[O:8][CH2:9][C:10]2([N:16]([CH2:17][CH2:18][C:19]3[CH:20]=[CH:21][C:22]([O:25][CH3:26])=[CH:23][CH:24]=3)[CH3:33])[CH2:11][CH2:12][CH2:13][CH2:14][CH2:15]2)[CH:28]=[CH:29][CH:30]=[CH:31][CH:32]=1

Participants

3

Reactant 2

HCID 197753001-Diphenylmethoxymethyl-1-(4-methoxyphenethylamino)cyclohexaneHCID 131717802Sodium cyanoborohydride formaldehyde

Product 1

HCID 197753151-Diphenylmethoxymethyl-1-[N-(4-methoxyphenethyl)-N-methylamino]-cyclohexane

Procedure

The title compound was prepared as described in Example 5, Method A, using 1-diphenylmethoxymethyl-1-(4-methoxyphenethylamino)cyclohexane (see Example 4) and sodium cyanoborohydride/formaldehyde. The title compound was obtained as a colourless oil (0.58 g, 66%), which was characterised from its 1H-n.m.r. spectrum.

Workup

  1. customThe title compound was prepared

Sources & evidence

ORD record
ord-dc8d9ab8baa4414e8a6d89cebc519ea9
Source dataset
uspto-grants-1993_03
Patent number
US05192765

Reaction notes

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