Potassium Carbonate → 1-(1H-Benzimidazol-2-yl)-4-piperidinemethanamine

HRID 1613203Notes

Reaction equation

HRID 1613203 reaction equation
[NH2:1][CH2:2][CH:3]1[CH2:8][CH2:7][NH:6][CH2:5][CH2:4]1.C(=O)([O-])[O-].[K+].[K+].Cl[C:16]1[NH:17][C:18]2[CH:24]=[CH:23][CH:22]=[CH:21][C:19]=2[N:20]=1>C1(C)C=CC=CC=1>[N:17]1[C:18]2[CH:24]=[CH:23][CH:22]=[CH:21][C:19]=2[NH:20][C:16]=1[N:6]1[CH2:7][CH2:8][CH:3]([CH2:2][NH2:1])[CH2:4][CH2:5]1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 235274-(Aminomethyl)piperidineHCID 785722-Chlorobenzimidazole

Product 1

HCID 197495451-(1H-Benzimidazol-2-yl)-4-piperidinemethanamine

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

45 g of 4-aminomethylpiperidine are placed in 500 ml of anhydrous toluene in the presence of 55 g of potassium carbonate and of 50 g of 2-chlorobenzimidazole. The mixture is subjected to reflux overnight. Aver evaporation and crystallization of the oily residue, the expected product is obtained after washing with dichloromethane.

Workup

  1. temperatureto reflux overnight
  2. customAver evaporation and crystallization of the oily residue

Sources & evidence

ORD record
ord-6fcff09a09b247baa4408307d14cdf61
Source dataset
uspto-grants-1993_03
Patent number
US05192775

Reaction notes

Loading…