Ethanol → HCID 24838526, compound

HRID 1613232Notes

Reaction equation

HRID 1613232 reaction equation
Cl[CH:2]([CH2:6][C:7]1[CH:12]=[CH:11][C:10]([N+:13]([O-:15])=[O:14])=[CH:9][CH:8]=1)[C:3](=O)[CH3:4].[C:16]([CH2:19][NH:20][C:21]([NH2:23])=[S:22])([OH:18])=[O:17].[CH2:24](O)[CH3:25]>>[CH3:4][C:3]1[N:23]=[C:21]([NH:20][CH2:19][C:16]([O:18][CH2:24][CH3:25])=[O:17])[S:22][C:2]=1[CH2:6][C:7]1[CH:12]=[CH:11][C:10]([N+:13]([O-:15])=[O:14])=[CH:9][CH:8]=1

Participants

4

Reactant 3

HCID 702EthanolHCID 3040094Glycine, N-(aminothioxomethyl)-HCID 19775550HCID 19775550, compound

Product 1

HCID 24838526HCID 24838526, compound

Procedure

7.6 g of 3-chloro-4-(4-nitrophenyl)butan-2-one and 4.5 g of N-carboxymethylthiourea (NH2CSNHCH2COOH) are dissolved in 100 ml of ethanol and refluxed for 12 hours. The reaction medium is concentrated and the residue is recrystallized from isopropanol to give 9.5 g of ethyl (4-methyl-5-(4-nitrobenzyl)thiazol-2-yl)aminoacetate.

Workup

  1. temperaturerefluxed for 12 hours
  2. concentrationThe reaction medium is concentrated
  3. customthe residue is recrystallized from isopropanol

Sources & evidence

ORD record
ord-bf0eaaaf71164490ac7f6f43c2af4ad0
Source dataset
uspto-grants-1993_03
Patent number
US05192781

Reaction notes

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