HCID 19775561, compound → HCID 19775564, compound

HRID 1613244Notes

Reaction equation

HRID 1613244 reaction equation
[CH2:1]([O:3][C:4]([NH:6][CH2:7][C:8]1[S:9][C:10]([CH2:16][C:17]2[CH:22]=[CH:21][C:20]([N+:23]([O-])=O)=[CH:19][CH:18]=2)=[C:11]([CH2:13][CH2:14][CH3:15])[N:12]=1)=[O:5])[CH3:2]>C(O)C.[Ni]>[CH2:1]([O:3][C:4]([NH:6][CH2:7][C:8]1[S:9][C:10]([CH2:16][C:17]2[CH:22]=[CH:21][C:20]([NH2:23])=[CH:19][CH:18]=2)=[C:11]([CH2:13][CH2:14][CH3:15])[N:12]=1)=[O:5])[CH3:2]

Participants

4

Reactant 1

HCID 19775561HCID 19775561, compound

Product 1

HCID 19775564HCID 19775564, compoundYield 46.1%

Reagents, catalysts & solvents 2

HCID 935NickelCatalystHCID 702EthanolSolvent

Procedure

4.7 g of 2-ethoxycarbonylaminomethyl-5-(4-nitrobenzyl)-4-propylthiazole (13 mmol) in 100 ml of ethanol are hydrogenated at room temperature under 1 atmosphere in the presence of 5 g of Raney nickel. The reaction mixture is filtered and then concentrated to give 2 g of 2-ethoxycarbonylaminomethyl-5-(4-aminobenzyl)-4-propylthiazole in the form of a beige powder melting at 126° C.

Workup

  1. filtrationThe reaction mixture is filtered
  2. concentrationconcentrated

Sources & evidence

ORD record
ord-c0aaec56c3fc49e09ce1edc220162fb0
Source dataset
uspto-grants-1993_03
Patent number
US05192781

Reaction notes

Loading…