Sodium Hydroxide → HCID 19775597, compound

HRID 1613256Notes

Reaction equation

HRID 1613256 reaction equation
[Cl-].[C:2]1([CH:8]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[CH2:9][N+:10]2[NH:11][CH:12]=[N:13][CH:14]=2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>O>[C:2]1([CH:8]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][CH3:26])[CH2:9][N:10]2[CH:14]=[N:13][CH:12]=[N:11]2)[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 131717804HCID 131717804, compound

Product 1

HCID 19775597HCID 19775597, compoundYield 78.5%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

To 11.7 g of the crude hydrochloride salt from Example 10 above in 200 ml of water is added 4.0 g (0.05 mole) of 50% sodium hydroxide. The mixture is stirred for 15 minutes and then the organic soluble material is extracted into 2×200 ml of ether. The combined extracts are washed with 2×50 ml of water, dried over anhydrous magnesium sulfate, and concentrated to give 8.3 g (78.5%) of the oil product.

Workup

  1. extractionthe organic soluble material is extracted into 2×200 ml of ether
  2. washThe combined extracts are washed with 2×50 ml of water
  3. dry with materialdried over anhydrous magnesium sulfate
  4. concentrationconcentrated

Sources & evidence

ORD record
ord-2cb63fd1af2b4ca9933cf80450082f35
Source dataset
uspto-grants-1993_03
Patent number
US05192783

Reaction notes

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